Microscope | July 2019

RESEARCH UNDER THE MICROSCOPE

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Leukemia Research Foundation Funds 12
Blood Cancer Research Projects

The Leukemia Research Foundation is proud to announce the funding of 12 new blood cancer research projects for the 2019-2020 funding cycle. The Leukemia Research Foundation provides one-year grants of $100,000 through its Hollis Brownstein Research Grants Program to New Investigators to facilitate pursuit of groundbreaking research ideas that could lead to significant breakthroughs.

Congratulations to the following list of grantees:

Stephanie O. Berg, D.O. – Cardinal Bernardin Cancer Center,
Loyola University Medical Center (Maywood, Illinois)
Germline Mutations Predispose to Familial Myeloproliferative Neoplasms

Mario A. Blanco, Ph.D. – University of Pennsylvania
(Philadelphia, Pennsylvania)
Dual Targeting of LSD1 and KAT6A to Induce Therapeutic Differentiation in AML

Hamza Celik, Ph.D. – Washington University School of Medicine
(St. Louis, Missouri)
Generation of a Faithful Patient-derived Xenograft Model of Myelofibrosis for
Pre-clinical Studies

Steven M. Chan, M.D., Ph.D. – Princess Margaret Cancer Centre (Toronto)
Repurposing Metformin to Prevent Blood Cancers and Cardiovascular Diseases Associated with TET2 Mutation-Driven Clonal Hematopoiesis

Raffaella Di Micco, Ph.D. – Ospedale San Raffaele (Milan, Italy)
Targeting of Epigenetic Drivers of Immune Evasion in Acute Myeloid Leukemia Relapses After Allogeneic HSCT

Daichi Inoue, M.D., Ph.D. – Institute of Biomedical Research and Innovation (IBRI) (Kobe City, Japan)
Understanding the Role of ZRSR2 Mutations in Myeloid Malignancies

Irum Khan, M.D. –University of Illinois at Chicago (Chicago, Illinois)
Targeting FOXM1 to Improve Treatment Responses in AML

Yongsoo Kim, Ph.D. – VU University (Amsterdam, Netherlands)
A Computational Framework to Model Cellular Interplays in the Tumor Microenvironment of B Cell Lymphoma

Rui Lu, Ph.D. – University of Alabama (Birmingham, Alabama)
A Novel Stemness Program with Epigenetic Dysregulation in
Acute Myeloid Leukemia

Michael Milyavsky, Ph.D. – Tel Aviv University (Tel Aviv, Israel)
Harnessing Stemness Reporter to Identify and Target Critical Dependency Genes in Human Leukemia Stem Cells

Christopher Ott, Ph.D. – Massachusetts General Hospital
(Charlestown, Massachusetts)
Deciphering Mechanisms of PAX5 Addiction in Lymphoma

Capucine Van Rechem, Ph.D. – Stanford University (Stanford, California)
Identify New Functions for PRMT5 in B-Cell Lymphoma to
Unravel Therapeutic Strategies

“The primary mission of the Leukemia Research Foundation is to fund research into the causes of and cures for blood cancers and providing grants to New Investigators is critically important,” said Leukemia Research Foundation Executive Director Kevin Radelet.

“Each year, federal funding becomes more difficult to secure and New Investigators with fresh, groundbreaking ideas can’t get the funding they need to develop their ideas and the data required for greater funding from the National Institutes of Health (NIH) and other sources. Leukemia Research Foundation funding not only advances blood cancer science but also jump-starts careers for these scientists.”

Albert C Shaw MD-PhD

Albert C. Shaw, M.D., Ph.D.

Understanding Early Life Impact of Vaccines

Yale Professor of Medicine (Infectious Diseases) Albert C. Shaw, M.D., Ph.D. and colleagues have made a discovery that can help to explain how the human body changes, at a molecular level, early in life. Read more here. Understanding these changes can help medical experts determine how to use vaccines to prevent disease.

Doctor Shaw’s research was funded by the Leukemia Research Foundation in 2005.

trygve_tollefsbol PhD

Trygve O. Tollefsbol, Ph.D.

Dedicated to Epigenetics

Trygve O. Tollefsbol, Ph.D., funded by the Leukemia Research Foundation in 2002, is a professor of Biology at the University of Alabama, Birmingham. His research focuses on the epigenetics of cancer and aging. His work throughout his career has focused on leukemia and other cancers. He leads a specialized laboratory.

Read more here.

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Research Study Opportunity for AML Patients and Caregivers

On behalf of a pharmaceutical sponsor, researchers at Inspire are seeking patients and caregivers of patients diagnosed with acute myeloid leukemia (AML) to share their experience and thoughts. The Leukemia Research Foundation is sharing the opportunity with those who may be interested in helping us and Inspire to accelerate research!

For this research study, participants will join a private online community hosted on Inspire, where researchers will ask about a different topic each month for six months (July through December). Those who actively engage in the research will receive a $50 Amazon gift card for every month they participate.

To learn if you qualify, please take this short survey. If you qualify and are selected to participate, you will be notified via email and given more details and instructions on how to join the community.

If you have any questions, please email team@inspire.com.

Please do not contact the Leukemia Research Foundation as we are just sharing this information and do not have and further details regarding this research opportunity.

EVENTS UNDER THE MICROSCOPE

Participants compete in the 25th Annual ABC 7 Gibbons 5K Run & 3K Walk in Chicago, IL on Thursday, June 13, 2019. Photo: Christopher Dilts / Leukemia Research Foundation

Big Success for the 25th Annual ABC 7 Gibbons 5K Run and 3K Walk

Cloudy skies gave way to sunshine just in time for the 25th Annual ABC 7 Gibbons 5K Run and 3K Walk on Thursday, June 13. More than 1,200 runners, walkers and volunteered enjoyed a fabulous evening in Chicago’s Grant Park to help fund blood cancer research and support the patient education and support programs of the Leukemia Research Foundation. Click here for results.

The run start was broadcast live on ABC 7 Chicago, anchored by event co-chairs Janet Davies and Dionne Miller. Click here to view the video. Top overall male and female runners crossed the finish line banner held by ABC 7’s Janet Davies and Batman, who was onsite supporting the cause.

ABC 7 Chicago has been the title sponsor of this event for 25 years and the Leukemia Research Foundation is grateful for its commitment and support of the Chicagoland blood cancer community.

Highlights of the day include interviews of Leukemia Research Foundation Executive Director Kevin Radelet and Team Bad Blood Captain Nancy Zurawski. Watch her interview here.

Participants enjoyed a post-event party in the park, food and drink, DJ Dan Luna and another opportunity to save lives by signing up for the marrow registry.

JA Golf-smaller

18th Angels in the Fairway Golf Outing

It is not too late to register for the 18th Angels in the Fairway Golf Outing, hosted by the Joey’s Angels Chapter of the Leukemia Research Foundation. Join us for golf and activities for the family at the Grand Geneva Resort and Spa in Lake Geneva, Wisconsin on Friday, August 9. The day includes breakfast and lunch for golfers and a fantastic dinner for all in the evening. Click here for registration and details.

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Prime Day to Fight Blood Cancers

Monday, July 15 and Tuesday, July 16 are Amazon Prime Days and members can support the Leukemia Research Foundation while shopping the deals on these days. Just click here to sign in to your online account and a portion of your purchase will support the Leukemia Research Foundation.

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Early Bird Savings: Punching Out Blood Cancers

Get your tickets early and save for the 2nd Annual Punching Out Blood Cancers, Saturday, September 28 from 6:00 p.m. until 9:00 p.m. at Joe’s on Weed Street in Chicago. Ticket are $45 per person until Wednesday, August 28. After that, prices increase. Network with young professionals while fighting blood cancers with members of the Affiliate Board of the Leukemia Research Foundation. Click here for details and tickets.

EVENTS IN FOCUS

August 2 - 4
Kingfish Shootout
Carrabelle, Florida

August 9
Joey's Angels Chapter
18th Angels in the Fairway

September
Blood Cancer Awareness Month

September 22
73rd Annual Medical Awards Luncheon

September 28
Affiliate Board of the
Leukemia Research Foundation
Punching Out Blood Cancers

October 26
Conquer Leukemia Chapter
Inaugural Casino Night
Peachtree City, Georgia

November 19
Dads' Chapter
Rockin' for a Cure

Leukemia Research Foundation

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